Lesson 05 – Granulating Copy – Solid Dose E-Training

Question 1 of 20

1. Question

The drying process for a wet granulation can be accomplished by all of the following except

A tray dryer
A fluid bed dryer
A single pot granulator
A dry granulator

Question 2 of 20

2. Question

Content Uniformity means that each dose has the same quantity of ingredients as all the others doses within the batch

True
False

Question 3 of 20

3. Question

Blend uniformity and Content uniformity are the same thing

True
False

Question 4 of 20

4. Question

A granule defined as _______________.

Particles of powder
Controlled agglomeration of particle powders
Fine particles that don't flow
Non-compressible particles

Question 5 of 20

5. Question

A high shear wet granulator is called that because:

It uses low levels of energy
It uses high levels of energy
It only turns on when the liquids are at a certain temperature
It works just like a fluid bed granulator

Question 6 of 20

6. Question

Which is wrong? The reasons for granulating are:

To reduce fines, improve flow and compressibility
To improve bulk density and content uniformity
To reduce segregation
To increase weight variation in tablet compression

Question 7 of 20

7. Question

A fluid Bed granulator can be used for granulating, drying or as a dryer only

True
False

Question 8 of 20

8. Question

Granules can be produced by either wet granulating or dry granulating

True
False

Question 9 of 20

9. Question

A jacketed granulator means

That the product bowl has a outer space between the inner bowl and outside so that hold or cold water or steam can be pumped through the jacket to help powders perform better
The inner bowl is wrapped with a blanket
Means that is it not GMP acceptable
Means that in the old days jackets were used to keep it warm

Question 10 of 20

10. Question

The dry granulating process my involve the use of

A wet granulator
A tablet press or roller compactor
Jacketed vessel to heat the liquid that will be sprayed onto the powders
High speed liquid injectors

Question 11 of 20

11. Question

Granules are only needed for compression and compressibility is not needed for capsules

True
False

Question 12 of 20

12. Question

Wet granulating is the use of a liquid suspensions that links powder particles together

True
False

Question 13 of 20

13. Question

Direct Compression means

Powders must be wet granulated
Powders must be dry granulated
Powders come ready to compress and don't need to be granulated
Granules are too large and must be milled

Question 14 of 20

14. Question

Powders that are dry granulated must be somewhat

Cohesive
Non-Cohesive
Dusty and non compressible
Wet and sluggish

Question 15 of 20

15. Question

Reasons for Dry Granulating

Eliminate fines, improve flow, control density
Increase the percentage of fines to help compression
Decrease yields and increase weight variations in compression
To cause the de-laminating process

Question 16 of 20

16. Question

A roller compactor

Densifies powders thru dry compaction
Makes powders fluffy
Sprays liquids forming oversize agglomerates
Is best used for capsules only

Question 17 of 20

17. Question

The higher the Angle of Repose the better the flow propertites

True
False

Question 18 of 20

18. Question

In the wet granulating process, particles are linked together forming granules

By the quantity of excipients that are added
By solution addition and residence time within the granulator
By the percentage of fine versus the percentage of small particles
By the drying process

Question 19 of 20

19. Question

A type of granulator used for wet granulating

Tumble Blender without an intensifier bar
Fluidized Bed Granulator
Chilsonator or roller compactor
High shear impact mill

Question 20 of 20

20. Question

Over-granulating means that the process went to far and particles form oversized agglomerates

True
False